UNCITI-BROCETA GROUP
Edinburgh Cancer Research UK Centre, MRC Institute of Genetics & Molecular Medicine
University of Edinburgh
2016
DEC 16 CONGRATULATIONS TO DR SAM MYERS!! He successfully passed his viva with minor revision
DEC 16 Thanks Dr Celine Cano (Newcastle University) for visiting our centre and giving a wonderful talk on the development of novel DNA-PK inhibitors.
NOV 16 Axon Medchem launches the new product eCF309. This highly selective mTOR inhibitor was discovered and has been produced for sale by our lab. Due to its high selectivity, this inhibitor has been listed in the Chemical Probes portal.
OCT 16 PUBLICATION Congratulations to Belén, whose research work on Pd-activated prodrugs of the HDAC inhibitor vorinostat has just been published in JMedChem
(OPEN ACCESS).
AUG 16 Asier is admitted as a Fellow of the Royal Society of Chemistry.
JUL 16 PUBLICATION
Review article on phenotypic drug discovery strategies with Scott Warchal and Neil Carragher, just published in Future Medicinal Chemistry
MAY 16 PUBLICATION Congratulations to Craig, whose research work on the development of novel SRC/nonABL inhibitors has just been published in JMedChem
(OPEN ACCESS).
APR 16 Asier gives the inaugural lecture at Diverciencia 2016 in his home town Algeciras (Spain). See TV news about the lecture here. See opinion article here.
APR 16 Asier speaks about the research developed by the Innovative Therapeutics Lab at the EICC as part of the InnovationNation series. See film here.
MAR 16 HIGHLIGHT
Craig's work (eCF309: a potent, selective and cell-permeable mTOR inhibitor) is featured in the Inside Front Cover of the March Issue of MedChemComm (RSC). This is a Special Issue ("New Talent: Europe") that showcases some of the top research from emerging investigators from Europe.
MAR 16 HIGHLIGHT
Craig's work (eCF309: a potent, selective and cell-permeable mTOR inhibitor) is featured in the Inside Front Cover of the March Issue of MedChemComm (RSC). This is a Special Issue ("New Talent: Europe") that showcases some of the top research from emerging investigators from Europe.
FEB 16 Our bid, supported by collaborators Prof Neil Carragher, Dr Liz Patton, Dr Paul Brennan and Prof Hing Leung, was one of the 9 winners across the UK. EPSRC’s Chief Executive, Professor Philip Nelson, said: “These Healthcare Technologies Challenge Award winners are our future research leaders who will be instrumental in ensuring the UK can meet the 21st century healthcare needs and thrive as a healthy nation.”
FEB 16 Life Sciences Minister George Freeman announces over £1M funding to our lab through the EPSRC Healthcare Technology Challenge Award.
FEB 16 The Royal Society of Edinburgh announces Asier as the recepient of the RSE/Patrick Neill Medal 2016 for his outstanding research work in biomedical technologies and innovative therapeutics through multi-disciplinary collaboration
JAN 16 PUBLICATION
Collaboration with Adam Byron and Val Brunton on resistance to HER2 targeted therapy, where they used Craig's SRC/nonABL kinase inhibitor eCF506, just published in Oncotarget (OPEN ACCESS)
JAN 16 Research proposal in collaboration with Dr Paul Brennan and Dr Dirk Sieger awarded CRUK Pioneer Award
JAN 16 Craig's MedChemComm paper selected HOT Article of 2016
2015
DEC 15 PUBLICATION Congratulations to Craig, whose research work on mTOR inhibitors has just been published in MedChemComm
(OPEN ACCESS). The article is published as part of the themed collection "New Talent: Europe"
DEC 15 Asier speaks about the bioorthogonal activation of anticancer glycosides at PACIFICHEM 2015 (Honolulu, USA)
NOV 15 PUBLICATION Congratulations to Sam, whose review on AXL inhibitors has been published in the Journal of Medicinal Chemistry
(OPEN ACCESS)
AUG 15 Asier presents the last research of the lab at the 250th ACS National Meeting & Exposition (Boston, USA)
JUL 15 CONGRATULATIONS TO DR CRAIG FRASER!! He successfully passed his viva and examiners just requested minor changes to the thesis manuscript
JUN 15 PUBLICATION
News & Views article highlighting the work reported by Vincent Rotello's lab on supramolecularly-regulated bioorthogonal catalysis and the future directions of the field published in Nat Chem
MAY 15 PUBLICATION
Collaborative work with Dr Pineda de las Infantas, Prof Molina and Dr Díaz-Mochón, from the University of Granada (Spain), identifies paradigm-changing DAPK1 inhibitors with pro-apoptotic activity. The work is published in Org Biomol Chem
APR 15 The University of Edinburgh promotes Asier to Reader in Medicinal Chemistry
MAR 15 PUBLICATION
Congratulations to Jason, whose work on bioorthogonal precursors of Floxuridine activated by Palladium chemistry (last chapter yet to be published of his thesis) has been just published in Scientific Reports
(OPEN ACCESS)
MAR 15 PUBLICATION
Collaboration with Dr Pineda de las Infantas and Dr Díaz-Mochón, from the University of Granada (Spain), on a novel synthesis of poly-substituted purines and their screening as trypanocidal agents published in Scientific Reports
(OPEN ACCESS)
2014
NOV 14 CONGRATULATIONS TO DR JASON WEISS, who has successfully passed his viva (examiners just requested minor corrections)
JUL 14 PUBLICATION Congratulations to Jason, Craig, Belén, Sam and Richard, whose work has been published in Frontiers in Chemistry, specialty in Medicinal and Pharmaceutical Chemistry
(OPEN ACCESS)
JUN 14 Patent application US8759104B2 on biodegradable transfection reagents (licensed to Deliverics Ltd) granted in the US
JUN 14 Jason's Nat Commun paper on 5FU prodrugs activated by heterogeneous palladium catalysis featured in Synform
MAY 14 Jason's J Med Chem paper selected ACS Editor Choice
APR 14 PUBLICATION
Congratulations to Jason, whose work on bioorthogonal Palladium-activatable procursors of the nucleoside analog gemcitabine has been accepted in the Journal of Medicinal Chemistry
(OPEN ACCESS)
MAR 14 Asier's radio interview in Hoy por Hoy (Radio Algeciras Cadena Ser, Spain), where he explains (in Spanish) the recent discovery reported in Nature Communations and how this novel technology could reduce the side effects of chemotherapy
MAR 14 Jason's paper featured in C&EN and Cosmos Magazine
FEB 14 News about Jason's paper published in the press (Metro, The Scotsman, The Herald, etc.) and reported in STV Evening News
JAN 14 PUBLICATION
Congratulations to Jason, whose work on inactive 5FU prodrugs activated by Pd(0) (first ever prodrug to become activated by extracellular metal catalysis) has been just accepted in Nature Communications
(OPEN ACCESS)
2013
DEC 13 Asier is appointed Associate Editor of Frontiers in Chemistry (specialty in Medicinal and Pharmaceutical Chemistry)
JUL 13 OUR NEW LAB IN THE SECOND FLOOR OF THE EDINBURGH CANCER RESEARCH CENTRE IS READY!!!
MAY 13 Asier is elected member of the RSE Young Academy of Scotland. Established by the Royal Society of Edinburgh in 2011 is the first and (currently) only Young Academy in the United Kingdom. The Young Academy of Scotland provides a platform for abling innovative young entrepreneurs, professionals and academics to have a coherent and influential voice, and to address the most challenging issues facing society
APR 13 Asier is recognized by the Centro Andaluz de Algeciras (Spain) with the Andaluz Especial Award of 2013
2012
NOV 12 Asier is interviewed in the radio (Hoy por Hoy, Radio Algeciras Cadena Ser, Spain) and by Spanish newspaper (Europa Sur) in relation to the Young Industrialist of the Year award he received from the Royal Society of Chemistry
JUN 12 News about Nature Protocols paper published in the Daily Express
MAY 12 PUBLICATION
Investigation and first definition of BioOrthogonal OrganoMetallic (BOOM) Chemistry published in Nature Protocols
MAY 12 The Royal Society of Chemistry recognizes Asier with the RSC YOUNG INDUSTRIALIST OF THE YEAR AWARD of 2012 "for his capacity to develop and lead the translation of novel concepts into products, along with his outstanding research/commercial early track record in the chemical sciences"
FEB 12 Deliverics Ltd runner-up of New Life Sciences Company in Scotland of 2012
2011
NOV 10 AWARD
Deliverics Ltd, spinout company founded by Asier, is awarded the Nexxus Most Promising Life Science Company of the Year by Nexxus Scotlant (East)
SEP 11 WE ARE A GROUP!!
Jason and Craig become the first two PhD students to work at the Innovative Therapeutics Lab
FEB 11 HIGHLIGHT
News about Nature Chemistry paper highlighted in Chemistry World
FEB 11 PUBLICATION
First investigation on Palladium-mediated chemistry inside cells published in Nature Chemistry
2010
NOV 10 AWARD
Asier is awarded the Nexxus Young Life Scientist of the Year by Nexxus Scotlant (East)
OCT 10 NEW START
Asier starts his new position as Academic Fellow / Principal Investigator at the Edinburgh Cancer Research Centre, funded by the Institute of Genetics & Molecular Medicine