Ana is from Granada (Spain) where she completed her BSc in Pharmacy (2004) and obtained her PhD working on protein-protein interaction inhibitors mediated by the nNOS PDZ domain (University of Granada, 2010). After holding a temporary lectureship in Organic Chemistry in the same university, she joined the Bradley group (University of Edinburgh) in 2011 as a postdoc. During this time, she worked on cell delivery systems via cleavable-linkers for molecular imaging. She started in the Unciti-Broceta lab in Nov 2014, where she is developing Pd-activatable precursors of bioactive small molecules for cancer therapy.
In her spare time, Ana enjoys spending time with her friends, classic films and running around everywhere.
Cath obtained her MChem from the University of Edinburgh, spending a year in Process R&D at AZ. She remained in Edinburgh for her PhD in the Cockroft group, using molecular balances to probe the effect of solvents on non-covalent interactions. She began her first postdoc in 2014 with the Clayden group in Manchester (moving with them to Bristol), in the field of foldamer chemistry. During this project she strengthened her expertise in supramolecular chemistry by investigating the communication of information between helical-peptide foldamers, and also gained research skills at the chemistry-biology interface, while exploring their ability to form ion-channels across lipid membranes. She joins the lab as a postdoc funded by CRUK, to develop Pd-activatable precursors of bioactive small molecules for cancer therapy.
Dr Teresa Valero
Teresa obtained her PhD from the University of Freiburg (Germany) in 2013. As an early stage researcher of a MSCA Research Training Network, she developed novel applications of impedance biosensors in brain cancer. During that time, she also worked as principal researcher for a SME-based European Project in the field of biosensors. She started her first postdoc in 2014, as Talentia postdoctoral Fellow (H2020 Co-fund), under the supervision of Prof Unciti-Broceta (UoE) and Dr Sanchez-Martín (Universidad de Granada) until 2016. During this project she focused on the development of novel nanotools for target engagement studies. After holding a lectureship in Pharmacology at Bradford University (2017), she joined the Unciti-Broceta´s lab as MSCA Fellow in 2018, where she is working in the development of novel kinase inhibitors against brain cancer.
Dr Shiao Chow
Shiao graduated in 2009 from the University of Queensland (Australia) with a 1st class hons Bachelor of Biotechnology degree. She started her PhD under the supervision of Prof D Fairlie. During this time, she worked in the interface of computational modelling, chemistry and biology to develop potent and selective serine protease inhibitors. Shiao pursued her first postdoct in 2014 as a Carl Tryggers Research Fellow with Assoc. Prof. L Odell at Uppsala University (Sweden). She led several methodology development projects to explore novel transformations focusing on palladium-, photoredox- and radical-mediated carbonylations, including the translation of these methodologies to 11C-radiochemistry. In 2016, Shiao began her second postdoc with the Nelson Group at the University of Leeds working on activity-directed synthesis of bioactive molecules. She joined the Unciti-Broceta lab in 2018 as a MSCA Fellow to develop cell-targeting nanobots.
Carolin grew up in Neustadt (Germany) and moved to Scotland in 2012 to complete a BSc (Hons) Biomedical Sciences (Pharmacology) at the University of Edinburgh. During her studies, she undertook an Amgen Scholar internship to research combination therapies in prostate cancer, as well as a summer internship at the Karolinska Institutet working with MTH1 inhibitors in Glioblastoma. She joined the Unciti-Broceta lab in 2016 for her Bachelor dissertation and then obtained a Principal's PhD scholarship and a Richard Brown scholarship to continue her investigations on the anticancer properties of the first in vivo-active SRC/nonABL inhibitor, eCF506, for her PhD.
Dan, from Sevenoaks in Kent, has recently moved to Edinburgh, having just completed a MChem (Hons) in Chemistry with Industrial Training at the University of Bath. As part of his first degree, he undertook an industrial placement with GlaxoSmithKline, based at the Medicines Research Centre (Stevenage). While at GSK, he worked on the development and synthesis of novel small molecule drugs for the treatment of idiopathic pulmonary fibrosis. On his return to Bath, his final year project, "Catalytic Arylnitrenium Ion Generation for Metal-Free Biaryl Synthesis", was completed under the supervision of Dr Alex Cresswell. He joined the Unciti-Broceta lab in 2017 to start his PhD, focusing on the rapid development of kinase inhibitors for the treatment of brain malignancies.
Cecilia C. Ayala-Aguilera
Cecilia was born in Mexico City. She obtained her BSc in Biological Pharmaceutical Chemistry (2013) from the National Autonomous University of Mexico. Then, Cecilia was awarded the CONACyT scholarship by the Mexican Government to study a MSc in Biotechnology at the University of Edinburgh (2016). Her master dissertation on the "Identification Peptides Binding to Ovotransferrins with Phage Display" was completed under the supervision of Professor Manfred Auer. She joined the Unciti-Broceta group as a PhD student founded by CONACyT (2018), to develop novel antiproliferative kinase inhibitors against esophageal cancer.
Stephen grew up in Dublin. He studied Medicinal Chemistry at Trinity College Dublin, where he undertook a final year research project into developing DNA FIT-probes. He then went on to continue his studies at Imperial College London where he completed an MRes in Drug Discovery and Development. During his time there he worked on the development of novel therapies for ER+ breast cancer. He joined the Unciti-Broceta lab as a MSCA fellow under the THERACAT project. His PhD will focus on the development of novel bio-orthogonal catalysis-based tools for cancer therapy.
Melissa van de L'Isle
Melissa grew up in the Netherlands and obtained her BSc in Chemistry and MSc in Chemical Biology, respectively from the University of Applied Sciences Hogeschool Utrecht and Leiden University. Her master thesis concerned the synthesis of non-covalent inhibitors for glucosylceramide synthase. She did an Erasmus internship focusing on the synthesis of 3’-C-ethynyl adenosine analogues at Ghent University (Belgium). Afterwards, she went on to work as technical assistant/ lab technician at LDC Dortmund (Germany). She joined the Unciti-Broceta group as a MSCA fellow as part of the THERACAT consortium in 2019 to work on the development and evaluation of new catalytic devices capable to mediate bioorthogonal chemistry in cell culture and in vivo.