PUBLICATIONS

(52) Nature Catalysis IN PRESS.

 

(51) H. W. Smith, A. Hirukawa, V. Sanguin-Gendreau, I. Nandi, C. R. Dufour, D. Zuo, K. Tandoc, M. Leibovitch, S. Singh, J. P. Rennhack, M. Swiatnicki, C. Lavoie, V. Papavasiliou, C. Temps, N. O. Carragher, A. Unciti-Broceta, P Savage, M. Basik, V. van Hoef, O. Larsson, Caroline L. Cooper, A. C. Vargas Calderon, Jane Beith, E. Millar, C. Selinger, V. Giguère, M. Park, L. N. Harris, V. Varadan, E. R. Andrechek, S. A. O’Toole, I. Topisirovic and W. J. Muller*. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Nature Communications 2019, 10, 2901.

 

(50) N. Fernández-Sáez, Belén Rubio-Ruiz, J. M. Campos, A. Unciti-Broceta, M. D. Carrión* and M. E. Camacho*. Purine derivatives with heterocyclic moieties and related analogs as new antitumor agents. Future Medicinal Chemistry 2019, 11, 83-95.

 

(49) C. Torres-Sánchez,*  A. M. Pérez-López, M. N. Alqahtani, A. Unciti-Broceta and B. Rubio-Ruiz. Design and manufacture of functional catalyst-carrier structures for the bioorthogonal activation of anticancer agents. New Journal of Chemistry 2019, 43, 1449-1458.

 

Featured as New Journal of Chemistry HOT ARTICLE   

(48) C. Adam, A. M. Pérez-López, L. Hamilton, B. Rubio-Ruiz, T. L Bray, D. Sieger, P. M. Brennan* and A. Unciti-Broceta*. Bioorthogonal Uncaging of the Active Metabolite of Irinotecan by Palladium‐Functionalized Microdevices. Chemistry, A European Journal 2018, 24, 16783-16790.

 

 

Featured as HOT PAPER and Frontispiece of issue 63 

(47) S. Sarvi, R. Crispin, Y. Lu, L. Zeng, T. D. Hurley, D. R. Houston, A. von Kriegsheim, C.-H. Chen, D. Mochly-Rosen, M. Ranzani, M. E. Mathers, X. Xu, W. Xu, D. J. Adams, N. O. Carragher, M. Fujita, L. Schuchter, A. Unciti-Broceta, V. G. Brunton, E. E. Patton*. ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells. Cell Chemical Biology 2018, 25, 1456-1469.

2010 - present

2010 - present

(46) T. Valero, A. Delgado-Gonzalez, J. D. Unciti-Broceta, M. V. Cano-Cortes, A. M. Pérez-López, A. Unciti-Broceta,* R. M. Sanchez-Martin*. Drug “Clicking” on Cell-Penetrating Fluorescent Nanoparticles for In Cellulo Chemical Proteomics. Bioconjugate Chemistry 2018, 29, 3154–3160.

 

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(45) T. L Bray, M. Salji, A. Brombin,  A. M. Pérez-López, B. Rubio-Ruiz, L. C. A. Galbraith, E. E. Patton, H. Leung* and A. Unciti-Broceta*. Bright insights into Palladium-triggered local chemotherapy. Chemical Science 2018, 9, 7354-7361.

 

Featured as 2018 Chemical Science HOT ARTICLE 

News covered by general media: Scotsman, The National.  

(43) S. H. Myers, C. Temps, V. G. Brunton and A. Unciti-Broceta*. Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening. Journal of Medicinal Chemistry 2018, 61, 2104–2110.

(41) A. Delgado-Gonzalez, E. Garcia-Fernandez, T. Valero, M. V. Cano-Cortes, M. J. Ruedas-Rama, A. Unciti-Broceta, R. M. Sanchez-Martin, J. J. Diaz-Mochon* and A. Orte*. Metallofluorescent Nanoparticles for Multimodal Applications. ACS Omega 2018, 3, 144-153.

 

(40) B. Rubio-Ruiz, T. L. Bray, A. M. Pérez-López and A. Unciti-Broceta*. Masking Strategies for the Bioorthogonal Release of Anticancer Glycosides. In: Z. J. Witczak, R. Bielski (Eds), Coupling and Decoupling of Diverse Molecular Units in Glycosciences (2018). Springer, Cham.

(39) A. M. Pérez-López, B. Rubio-Ruiz, V. Sebastián, L. Hamilton, C. Adam, T. L. Bray, S. Irusta, P. M. Brennan, G. C. Lloyd-Jones, D. Sieger, J. Santamaría* and A. Unciti-Broceta*. Gold-Triggered Uncaging Chemistry in Living Systems. Angewandte Chemie International Edition 2017, 56, 12548-12552.

 

Featured in the Inside Back Cover

Widely covered by specialized and mainstream media:

BBC, Sputnik Int., RTE, The Medicine Maker ("The Golden Touch")

(38) B. Rubio-Ruiz, J. T. Weiss and A. Unciti-Broceta*. Efficient Palladium-Triggered Release of Vorinostat from a Bioorthogonal Precursor. Journal of Medicinal Chemistry 2016, 59, 9974–9980.

(37) S. J. Warchal, A. Unciti-Broceta and Carragher*. Next-generation phenotypic screening. Future Medicinal Chemistry 2016, 8, 1331-1347.

(36) C. Fraser, J. C. Dawson, R. Dowling, D. R. Houston, J. T. Weiss, A. Munro, M. Muir, L. Harrington, S. P. Webster, M. C. Frame, V. G. Brunton, E. E. Patton, N. O. Carragher and A. Unciti-Broceta*. Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. Journal of Medicinal Chemistry 2016, 59, 4697–4710.

 

 

 

(35) H. Creedon, L. Gómez-Cuadrado, Ž. Tarnauskaitė, J. Balla, M. Canel, K. G. MacLeod, B. Serrels, C. Fraser, A. Unciti-Broceta, N. Tracey, T. Le Bihan, T. Klinowska, A. H. Sims, A. Byron* and V. G. Brunton*. Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy. Oncotarget 2016, 7, 11539-11552.

(34) C. Fraser, N. O. Carragher and A. Unciti-Broceta*. eCF309: a potent, selective and cell-permeable mTOR inhibitor. MedChemComm 2016, 7, 471-477.

 

 

 

 

 

 

 

 

 

 

Featured as HOT Article of 2016 and Inside Front Cover

Contribution to the themed collection "New Talent: Europe"

 

(33) S. H. Myers, V. G. Brunton and A. Unciti-Broceta*. AXL inhibitors in cancer: A medicinal chemistry perspective. Journal of Medicinal Chemistry 2016, 59, 3593–3608.

(32) A. Unciti-Broceta*. Bioorthogonal catalysis: Rise of the nanobots. Nature Chemistry 2015, 7, 538-539.

 

(31) M. J. Pineda de las Infantas, S. Torres-Rusillo, J. D. Unciti-Broceta, P. Fernandez-Rubio, M. A. Luque-Gonzalez, M. A. Gallo, A. Unciti-Broceta, I. J. Molina and J. J. Diaz-Mochon*. Synthesis of 6,8,9 poly-substituted purine analogue libraries as pro-apoptotic inducers of human leukemic lymphocytes and DAPK-1 inhibitors. Organic & Biomolecular Chemistry 2015, 13, 5224-5234.

 

(30) J. T. Weiss, N. O. Carragher and A. Unciti-Broceta*. Palladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy. Scientific Reports 2015, 5, 9329.

 

(29) M. J. Pineda de las Infantas y Villatoro,* J. D. Unciti-Broceta, R. Contreras-Montoya, J. A. Garcia-Salcedo, M. A. Gallo Mezo, A. Unciti-Broceta* and J. J. Diaz-Mochon*. Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity. Scientific Reports 2015, 5, 9139.

 

(28) J. T. Weiss, C. Fraser, B. Rubio-Ruiz, S. Myers, R. Crispin, J. C. Dawson, V. G. Brunton, E. E. Patton, N. O. Carragher and A. Unciti-Broceta*. N-Alkynyl Derivatives of 5-Fluorouracil: Susceptibility to Palladium-Mediated Dealkylation and Toxigenicity in Cancer Cell Culture. Frontiers in Chemistry 2014, 2, 56.

 

(27) J. T. Weiss, J. C. Dawson, C. Fraser, W. Rybski, C. Torres-Sánchez, M. Bradley, E. E. Patton, N. O. Carragher and A. Unciti-Broceta*. Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine. Journal of Medicinal Chemistry 2014, 57, 5395-5404.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Featured as ACS’ Editor Choice.

(26) J. T. Weiss, J. C. Dawson, K. G. Macleod, C. Fraser, W. Ribski, C. Torres-Sánchez, E. E. Patton, M. Bradley, N. O. Carragher & A. Unciti-Broceta*. Extracellular Palladium-Catalyzed Dealkylation of 5-Fluoro-1-Propargyl-Uracil as a Bioorthogonally-Activated Prodrug Approach. Nature Communications 2014, 5, 3277.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Featured in C&EN (Issue 8, p. 6, News of The Week), Synform (July Issue, Synfacts 2014, 10(07), A90-92) and widely covered by specialized (Cosmos Magazine, Elsevier Materials Today, etc.) and mainstream media (>25 news outlets, e.g. STV, The Herald, The Scotsman, ScienceDaily, ABC, and translated into > 10 languages).

(25) L. H. Wong, A. Unciti-Broceta, R. White, M. Spitzer, M. Tyers & L. Harrington*. A yeast chemical genetic screen identifies new inhibitors of human telomerase. Chemistry & Biology 2013, 20, 333-340.

(24) M. R. Yusop*, A. Unciti-Broceta & M. Bradley. A Highly Sensitive Fluorescent Viscosity Sensor. Bioorganic & Medicinal Chemistry Letters 2012, 22, 5780-5783.

(23) A. Unciti-Broceta*, E. M. V. Johansson, R. M. Sánchez-Martín & M. Bradley*. Synthesis of Polystyrene Microspheres and Functionalization with Pd0 Nanoparticles to Perform Bioorthogonal Organometallic Chemistry in Living Cells. Nature Protocols 2012, 7, 1207-1218.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

First definition of Bioorthogonal Organometallic (BOOM) Chemistry. News about the article was covered by the Daily Express (30 Jun 2012).

(22) A. Unciti-Broceta, J. J. Díaz Mochón, R. M. Sanchez-Martin* & M. Bradley*. The Use of Solid Supports to Generate Nucleic Acid Carrier. Accounts of Chemical Research 2012, 45, 1140–1152.

(22) N. Carragher*, A. Unciti-Broceta & D. Cameron. Advancing cancer drug discovery towards more agile development of targeted combination therapies. Future Medicinal Chemistry 2012, 4, 87-105.

(20) A. Liberska, A. Lilienkampf, A. Unciti-Broceta* & M. Bradley*. Solid-Phase Synthesis of Arginine-Based Double-Tailed Cationic Lipopeptides: Potent Nucleic Acid Carriers. Chemical Communications 2011, 47, 12774-12776.

 

 

 

 

 

 

 

 

 

 

 

Compounds described in this article were patented and licensed to Deliverics Ltd.

(19) K. Dhaliwal*, G. Escher, A. Unciti-Broceta, N. McDonald, A. J. Simpson, C. Haslett & M. Bradley*. Far Red and NIR Dye-Peptoid Conjugates for Efficient Immune Cell Labelling and Tracking in Preclinical Models. MedChemComm 2011, 2, 1050-1053.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Featured in the front cover of the No. 11 issue of MedChemComm.

(18) M. R. Yusop, A. Unciti-Broceta, R. M. Sánchez-Martín, E. M. V. Johansson & M. Bradley*. Palladium-Mediated Intracellular Chemistry. Nature Chemistry 2011, 3, 241–245.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Featured in Chemistry World (Issue 3, 2011, RSC) and Synform (May Issue, 2011, Thieme Publisher). News of the discovery was widely covered by general media: TV (STV), radio (BBC1) and press (The Times, The Scotsman, Metro, Scottish Daily Express, The Herald, etc.).

(17) A. Unciti-Broceta*, L. Moggio, K. Dhaliwal, K. Finlayson, C. Haslett & M. Bradley*. Safe and Efficient In Vitro and In Vivo Gene Delivery: Tripodal Cationic Lipids with Programmed Biodegradability. Journal of Materials Chemistry 2011, 21, 2154-2158.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Compounds described in this article were patented and licensed to Deliverics Ltd.

(16) K. Dhaliwal*, L. Alexander, G. Escher, A. Unciti-Broceta, M. Jansen, N. Mcdonald, J. M. Cardenas-Maestre, R. Sanchez-Martin, J. Simpson, C. Haslett & M. Bradley*. Multimodal Molecular Imaging approaches to detect primary cells in preclinical models. Faraday Discussions 2011, 149, 107-114.

 

 

 

 

Before 2010

(15) A. Unciti-Broceta*, M. N. Bacon & M. Bradley*. Chemical Strategies for the Preparation of Synthetic Transfection Vectors. Topics in Current Chemistry 2010, 296, 15-49.

 

Part of the Nucleic Acid Transfection Volume.

 

(14) A. Unciti-Broceta*. The 3rd International Symposium “Cellular Delivery of Therapeutic Macromolecules”. Therapeutic Delivery 2010, 1, 511–515.

 

(13) A. Unciti-Broceta*. MedChem Europe 2010 - Select Biosciences' Sixth Annual Meeting. IDrugs 2010, 13, 366–368.

 

Originally published by Thomson Pharma (2010, Thomson Reuters Scientific).

 

(12) A. Unciti-Broceta*, M. J. Pineda, M. A. Gallo & A. Espinosa. Synthesis of 9-alkyl-6-amino[1,2,4]triazolo[3,4-c]-5-azaquinoxalines. Mild and Effective SNAr Amination of Highly Electron-Poor Heterocycles. Tetrahedron Letters 2010, 51, 2262–2264.

 

(11) A. Unciti-Broceta, M. R. Yusop, P. Richardson, J. Walton & M. Bradley*. A fluorescein-derived anthocyanidin-inspired pH sensor. Tetrahedron Letters 2009, 50, 3713–3715.

 

Part of the special issue commemorating the 50th Anniversary of Tetrahedron Letters.

 

(10) A. Unciti-Broceta, F. Diezmann, C. Y. Ou-Yang, M. A. Fara, M. Bradley*. Synthesis, Penetrability and Intracellular Targeting of Fluorescein-Tagged Peptoids and Peptide-Peptoid Hybrids. Bioorganic & Medicinal Chemistry 2009, 17, 959-966.

 

Part of the special issue honouring the Tetrahedron Young Investigator Award 2006 “Jonathan Ellman”.

 

(9) A. Liberska, A. Unciti-Broceta & M. Bradley*. Very Long-Chain Fatty Tails for Enhanced Transfection. Organic & Biomolecular Chemistry 2009, 7, 61-68.

 

(8) S. Pernagallo,† A. Unciti-Broceta,† J. J. Díaz Mochón & M. Bradley*. Deciphering cellular morphology and biocompatibility using polymer microarrays. Biomedical Materials 2008, 3, 034112 (6pp). † Equal contribution.

 

Part of the special issue Advanced Processing Routes for Tissue Engineering and Regenerative Medicine.

 

(7) A. Unciti-Broceta, E. Holder, L. J. Jones, B. Stevenson, A. R. Turner, D. J. Porteous, A. C. Boyd & M. Bradley*. Tripod-Like Cationic Lipids as Novel Gene Carriers. Journal of Medicinal Chemistry 2008, 51, 4076–4084.

 

Featured in SciBX, 1(25); doi:10.1038/scibx.2008.611 (Nature Publishing Group).

 

(6) S.-E. How, A. Unciti-Broceta, R. M. Sánchez-Martín & M. Bradley*. Solid-phase synthesis of a lysine-capped bis-dendron with remarkable DNA delivery abilities. Organic & Biomolecular Chemistry 2008, 6, 2266–2269.

 

(5) A. Unciti-Broceta, J. J. Díaz Mochón, H. Mizomoto & M. Bradley*. Combining Nebulization-Mediated Transfection and Polymer Microarrays for the Rapid Determination of Optimal Transfection Substrates. Journal of Combinatorial Chemistry 2008, 10, 179–184.

 

Featured in Faculty of 1000 PRIME (Biol. Rep. Ltd)

 

(4) F. Khan, R. Zhang, A. Unciti-Broceta, J. J. Díaz-Mochón & M. Bradley*. Flexible Fabrication of Microarrays of Microwells. Advanced Materials 2007, 19, 3524-3528.

 

(3) A. Unciti-Broceta*, M. J. Pineda-de-las-Infantas, M. A. Gallo & A. Espinosa*. Reduction of Different Electron-Poor N-Heteroarylhydrazines in Strong Basic Conditions. Chemistry, a European Journal 2007, 13, 1754-1762.

 

(2) A. Unciti-Broceta, M. J. Pineda, J. J. Díaz-Mochón, R. Romagnoli, P. G. Baraldi & A. Espinosa*. Regioselective Synthesis of 9-Alkyl-6-chloropyrido [3,2-e][1,2,4]triazolo[4,3-a]pyrazines. Reactivity of Aliphatic and Aromatic Hydrazides. Journal of Organic Chemistry 2005, 70, 2878-2880.

 

Featured in ChemInform, 36 (34), 219; doi:10.1002/chin.200534219 (Wiley)

 

(1) P. G. Baraldi*, A. Unciti-Broceta, M. J. Pineda de las Infantas, J. J. Díaz-Mochón, A. Espinosa & Romeo Romagnoli. An efficient one-pot synthesis of 6-alkoxy-8,9-dialkylpurines via reaction of 5-amino-4-chloro-6-alkylaminopyrimidines with N,N-dimethylalkaneamides and alkoxide ions. Tetrahedron 2002, 58, 7607-7611.

 

Featured in ChemInform, 34 (1), 158; doi:10.1002/chin.200301158 (Wiley)

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