The Unciti-Broceta Group is based at the Edinburgh Cancer Research UK Centre, part of the MRC Institute of Genetics and Molecular Medicine of the University of Edinburgh, where Prof Unciti-Broceta established the chemistry section of the Institute in 2010.
The lab explores novel chemical strategies to improve the efficacy and safety of cancer treatments. This includes development of highly-selective inhibitors of kinases involved in cancer and novel prodrug strategies aimed at improving the clinical use of well-established chemotherapy drugs.
JAN 20 PUBLICATION Congratulations to Tere, Dan and the rest of the team, whose research work on phenotypic screening of new kinase inhibitors against glioma has just been published in the special issue on Phenotypic Drug Discovery in Bioorganic & Medicinal Chemistry
DEC 19 CONGRATULATIONS TO DR CAROLIN TEMPS!! She successfully passed her viva with minor revisions
DEC 19 PUBLICATION Congratulations to Olga, Carolin, Beatrice and Sam, whose research work on a novel macrocyclic construct with activity against AXL kinase, has just been published in ACS Omega
DEC 19 Asier presents the last developments on bioorthogonal catalysis at CHAINS 2019 (Vendhoven, Netherlands).
NOV 19 Asier speaks at the NCRI Cancer Conference (Glasgow, UK) about the preclinical investigations with the selective SRC inhibitor eCF506.
OCT 19 Asier is honoured to give a plenary lecture at UCRA 2019 (Zaragoza, Spain).
OCT 19 HIGHLIGHT Our work entitled Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis is featured in News & Views article by Prof Xiaogang Qu in Nature Catalysis
AUG 19 PUBLICATION Congratulations to Belén and Ana, whose research work on Pd-loaded exosomes for targeted bioorthogonal catalysis, a collaboration with Santamaría's lab (Universidad de Zaragoza), has just been published in Nature Catalysis
AUG 19 VISITING STUDENT
The lab welcomes Eva Russo, High School student from Algeciras (Spain) that won a Diverciencia scholarship to visit our lab and learn how a drug discovery lab works
JUL 19 PUBLICATION Congratulations to Carolin, whose contribution to the fantastic work of Dr Harvey Smith and Prof William Muller (McGill University, Canada) on the ErbB2-SRC axis in breast cancer, has just been published in Nature Communications
JUN 19 B&B2019 SYMPOSIUM
Thanks to all speakers, flash and poster presenters and delegates for their participation at the second edition of Bioorthogonal & Bioresponsive! The event was a success with over 90 delegates from eight different countries and fantastic science. Looking forward to the 3rd edition in 2021!!